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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo

Is surgery the only option for bone-on-bone?

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Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

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Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

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SoftWave Tissue Regeneration Technologies Receives FDA Clearance for Blood Circulation Increase, Minor Aches and Pains Relief and Connective Tissue Activation

Treatment for osteonecrosis of the femoral head

Baker’s Cysts

Best Medical Devices for Treating Baker’s Cysts

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Softwave vs radial

Radial Shockwave Therapy Machines Compared 

Best Noninvasive Options for Regenerative Back Treatment Without Injections

Best Options for Regenerative Back Treatment Without Injections

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The influence of comorbidities – ESWT for chronic soft tissue wounds

UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

EPAT Therapy Costs for Patients & Practices

Shock Wave Therapy Compared with Intramedullary Screw Fixation for Nonunion of Proximal Fifth Metatarsal Metaphyseal-Diaphyseal Fractures

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Project: SoftWaves to prevent opioid addiction and to help addicts in their recovery.

Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Low Intensity Shock Wave Treatment for Erectile Dysfunction-How Long Does the Effect Last?

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

Acoustic Field of a Ballistic Shock Wave Therapy Device

Effectiveness of Extracorporeal Shock Wave Lithotripsy to Treat Dystrophic Calcinosis Cutis Ulcers

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

Comparative SWT Data to Evaluate Competing Technologies in the Treatment of Penile Connective Tissue for Improved Erectile Function

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Extracorporal SoftWave Treatment to Improve Nerve Regeneration

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MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

Cellulite and focused extracorporeal shockwave therapy for non-invasive body contouring: a randomized trial.

Impact of Extracorporeal Shockwave Therapy on Tooth Mobility in Adult Orthodontic Patients: A Randomized Single-Center Placebo-Controlled Clinical Trial

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How to Manage Pain Without Drugs

The influence of comorbidities and etiologies on the success of extracorporeal shock wave therapy for chronic soft tissue wounds: midterm results.

Macrophage migration induces angiogenesis

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears.

COVID-19 pneumonia: different respiratory treatment for different phenotypes?

​Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets

Shock wave therapy for osteoinduction

​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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The Basic Science Behind Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: a single-center, randomized, placebo-controlled clinical trial.

Effective Medical Devices for Temporomandibular Joint Dysfunction

Effective Medical Devices for Temporomandibular Joint Dysfunction

Effects of Low-Energy Shock Waves on Oral Bacteria

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IVSWT Water Bath V2.0 Manual

Alteration Of Inflammatory Response By Shock Wave Therapy Leads To Reduced Calcification Of Decellularized Aortic Xenografts In Mice.

Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy

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Extracorporeal shock wave therapy effectively prevented diabetic neuropathy

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Cleveland Clinic – Low Intensity Shockwaves In Urology

Extracorporeal shock wave therapy for nonunion of the tibia

Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis

Best Medical Devices for Treating Patellar Tendinitis

Best Medical Devices for Treating Patellar Tendinitis

Doctor Uses Shockwave Therapy to Heal Nearly Severed Foot

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Best Medical Devices for Treating Achilles Tendinitis

Best Medical Devices for Treating Achilles Tendinitis

Spark Wave® Therapy Improves Cardiac Function

ESWT Therapy for Treatment of Keloid Scars

SoftWave Celebrates Pro Success of Golfer Jake Peacock and Baseball Player Reid Worley, Highlighting Injury Prevention Breakthroughs

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Extracorporeal Shockwave Therapy for Arthritis Treatment

Fully healed, Ordonez flourished for Tigers using ESWT

The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

Focused Shockwave Therapy Efficacy & Alternatives

Focused Shockwave Therapy Efficacy & Alternatives

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Alternatives to Surgery

Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

Dr Irwin Goldstein Dinner Presentation – Nashville

Regenerative Treatments in Sports and Orthopedic Medicine for Clinicians in 2025

Regenerative Treatments in Sports and Orthopedic Medicine for Clinicians in 2025

Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

miR-19a-3p Containing Exosomes Improve Function of Ischaemic Myocardium Upon Shock Wave Therapy

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“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells

Case Series of Weekly Low Intensity Shock Wave Therapy for Erectile Dysfunction

SoftWave on Elbow

Radial Shockwave Therapy Benefits & Alternatives

Pulsewave Therapy- Mechanism of Action and Clinical Indications

Pulsewave Therapy Explained: Mechanism of Action and Clinical Indications

Physical Rehabilitation Using Shockwave Therapy

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FUNDAMENTALS OF VIBRATION-INDUCED, CELL POLARIZING TREATMENT MALIGNER DISEASES

Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study

Gainswave Machines: Cost, Efficacy, & Alternatives

Gainswave Machines: Cost, Efficacy, & Alternatives

Low-energy shock waves treatment induces angiogenesis in ischemic muscle by stimulation of Toll-like receptor 3 signalling

SoftWave vs Shockwave Technology Explained 

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Top Surgeon: SoftWave ‘a superior way to make tissue want to heal’

Chronic Tendonitis Treatment When Injections Have Failed

Chronic Tendonitis Treatment When Injections Have Failed

International Society for Medical Shockwave Treatment- ESWT BASIC PHYSICAL PRINCIPLES

Shockwave Therapy for the Treatment of Cancer

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptoms in a first-in-man trial

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Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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The Applied Mechanical Vibration as Extracorporeal Shock Wave

​Spark Waves® in Neurodegenerative Diseases – Concept for the Treatment of Alzheimer’s and Parkinson’s Disease

Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

Alternative Treatment using Shockwave for Erectile Dysfunction

Extracorporeal shockwave therapy as supplemental therapy for closure of large full thickness defects – Rat full -thickness skin graft model

OmniWave Shockwave Machines: Efficacy & Alternatives Explained

Effect of shockwave therapy on orthodontic tooth movement

Comparing Shockwave Therapy Machine Costs

Shockwave + Biologic Regeneration: Two Paths to Healing, One Goal

Regenerative Restorative Care Treatments Post Knee Surgery

Regenerative Restorative Care Treatments Post Knee Surgery

4 U. S. Patents issued on July 19, 2022

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The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification

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Influence of medical shock waves on healthy muscle tissue

Shockwave Therapy: Does it Hurt?

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Periodontal Cytokines Profile Under Orthodontic Force and Extracorporeal Shock Wave Stimuli in a Rat Model

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Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

Low-intensity extracorporeal shock wave therapy for erectile dysfunction after radical prostatectomy

Test43212

Managing Pain with Shockwave Therapy for Muscles

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Storz Duolith Machines- Cost, Efficacy, & Alternatives

Storz Duolith Machines Compared

A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Extracorporeal Shock Wave Therapy Induces Alveolar Bone Regeneration

Focal Shockwave Therapy Mechanisms and Efficacy Explained

Focal Shockwave Therapy Mechanisms and Efficacy Explained

Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

SoftWave’s New Leadership Team Accelerating Commercial Growth and Market Expansion

Linear Shockwave Therapy in Clinical Practice- Evidence and Mechanisms

Linear Shockwave Therapy Mechanisms and Efficacy Explained

Storz Masterpuls Machines: Cost, Efficacy, & Alternatives 

End-stage Heart Failure with COVID-19: Strong Evidence of Myocardial Injury by 2019-nCoV

Exploring Regenerative Shoulder Treatment for Rotator Cuff and Overuse Injuries

Regenerative Shoulder Treatment for Rotator Cuff and Overuse Injuries

Prospective Randomized Trial of Accelerated Re-Epithelization of Skin Graft Donor Sites Using Extracorporeal Shock Wave Therapy

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Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

Benefits of Spark Wave Therapy in neuronal regeneration

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Effect of penile rehabilitation with low intensity extracorporeal shock wave therapy

Extracorporeal shock waves Improve pareses in 8 cases of spinal cord injury and 3 cases of myelomeningocele.

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Alternatives to Cortisone Shots for Joint Pain Relief

Alternatives to Cortisone Shots for Joint Pain Relief

Dermapace Machines- Cost, Efficacy, & Alternatives

Dermapace Machines: Cost, Efficacy, & Alternatives

Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.

In vitro characterization and simulation of shockwaves by optical phase contrast imaging, computational modeling and acoustic measurement.

Shock wave therapy enhances neuronal sprouting and improves neuronal survival

Athletic therapy (Mts-Science)

Extracorporeal Shockwave Treatment Impedes Tooth Movement in Rats

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Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis

Shock Waves Reach Dental Implantology (Spanish)

​Shockwaves induce osteogenic differentiation of human mesenchymal stem cells through ATP release and activation of P2X7 receptors

Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

​The biologic effects of SoftWaves and rationale for spine and brain therapy

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Low Intensity Shock Wave Therapy: Regenerative Therapy for Erectile Dysfunction

Knee Pain Relief through Advanced Shockwave Therapy

SoftWave: Leading the Way in Knee Pain Relief through Advanced Shockwave Therapy

Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures

Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro

What Is Pulse Wave Therapy & Does It Work for Patients?

What Is Pulse Wave Therapy & Does It Work for Patients?

Is it possible to change the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

​Current research in this field is focused on shockwave therapy and on the role of inflammation and innaty immunity in myocardial infarction.

How Does Shockwave Therapy Work?

Golfer’s Secret Weapon for Injury Prevention: SoftWave TRT

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Extracorporeal shockwave therapy induces alveolar bone regeneration

Best Medical Devices for Treating Tennis & Golfer’s Elbow

Best Medical Devices for Treating Tennis & Golfer’s Elbow

Neuropathy

Shockwave Therapy for Neuropathy

Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy

The Effects of Extracorporeal Shock Wave Therapy in Patients with Coccydynia: A Randomized Controlled Trial

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Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

The Role of the Low-Intensity Extracorporeal Shockwave Therapy on Penile Rehabilitation After Radical Prostatectomy: A Randomized Clinical Trial

Treatment of stress urinary incontinence

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Effectiveness of the Electromagnetic Shock Wave Therapy in the Treatment of Cellulite

Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells

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​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

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Zimmer Shockwave Therapy: Cost, Efficacy, and Alternatives

Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model

Zimmer enPulsPro Shockwave Machines-

Zimmer enPulsPro Shockwave Machines: Efficacy & Alternatives

Peripheral Nerve Regeneration

Peripheral Nerve Regeneration

Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions

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opioids united states

FDA Tightens Opioid Warning Labels: Here’s the Non-Invasive Alternative Changing Pain Care

Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function

Shock waves promote spinal cord repair via TLR3

Extracorporeal shock wave therapy (ESWT) in urology:a systematic review of outcome in Peyronie’s disease, erectile dysfunction and chronic pelvic pain

Adhesive Capsulitis Management with Advanced Shockwave Therapy

SoftWave: Empowering Adhesive Capsulitis Management with Advanced Shockwave Therapy

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Piezowave Therapy Efficacy & Alternatives Explained

Piezowave Therapy Efficacy & Alternatives Explained

Extrakoprorale Stoßwellentherapie am Knochen – Voodoo oder Therapieoption?

Better lithotripsy on the horizon: an interview with James E. Lingeman, MD.

Electromagnetic Shockwave Therapy Mechanisms & Efficacy

Electromagnetic Shockwave Therapy Mechanisms & Efficacy

ESWT for retracting scars of the hand

Shockwave Therapy for Muscle Pain and Injuries

Shockwave Therapy for Muscle Pain and Injuries

Shockwave Therapy for Achilles Tendonitis

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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

SoftWave Therapy Averts Amputation for Former College Football Coach

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Acoustic Wave Therapy vs Shockwave Therapy

Low Intensity Shockwave Therapy vs High Intensity: Which Works Best?

Extracorporeal shock wave treatment of capsular fibrosis after mammary augmentation

Penile low intensity shock wave therapy for PDE5i non-responders suffering from vasculogenic Erectile Dysfunction since 2 to 10 years: A prospective, randomized, placebo-controlled study

SoftWave TRT vs Storz Shockwave Machines Compared

Shock wave treatment for in vitro engineering applications

Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1)

Shockwave therapy in stress fractures

New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

Using Sound to Battle Opioid Crisis

Extracorporeal Shock Wave Therapy

Shockwave Therapy for Plantar Fasciitis

Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

Shockwave Therapy Contraindications- When Not to Use It

Shockwave Therapy Contraindications: When Not to Use It

Effective Medical Devices for Treating Patellar Tendonitis 

Effective Medical Devices for Treating Patellar Tendonitis 

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

The Best Alternatives to Rotator Cuff Surgery

Alternatives to Rotator Cuff Surgery

Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

First Report for Unfocused Low Intensity SoftWave® Therapy (uESWT ) for Nocturia and Erectile Dysfunction (ED)

The Clinician’s Guide to Shockwave Therapy- Evidence, Safety, and Technology

The Clinician’s Guide to Shockwave Therapy: Evidence, Safety, and Technology

Extracorporeal Magnetic Transduction Therapy Explained

Extracorporeal Magnetic Transduction Therapy Explained

Comparative study of shockwave therapy and low-level laser therapy effects in patients with myofascial pain syndrome of the trapezius.

Can You Use a Shockwave Therapy Machine at Home?

Extracorporeal Shock Wave Therapy as an Adjunct Wound Treatment

TISSUE REGENERATION TECHNOLOGIES, LLC Establishment Registration & Device Listing

Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis​

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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