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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Effects of Extracorporeal Shockwave Therapy on Patients with Chronic Low Back Pain and Their Dynamic Balance Ability

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Non‑surgical Regenerative Treatments Integrating with PT

Non‑surgical Regenerative Treatments Integrating with PT

MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

​Extracorporeal shock waves as curative therapy for varicose veins? – (Fiorenzo Angehrn, Christoph Kuhn, Ortrud Sonnabend, Axel Voss)

The Assessment of New Bone Formation Induced by Unfocused Extracorporeal Shock Wave Therapy Applied on Pre-Surgical Phase of Distraction Osteogenesis

Shock wave therapy enhances neuronal sprouting and improves neuronal survival

Alternatives to Surgery

Extracorporeal Shock-Wave Therapy Compared with Surgery for Hypertrophic Long-Bone Nonunions

Shock wave treatment after hindlimb ischemia results in increased perfusion and M2 macrophage presence

Complementary effect of L-citrulline supplementation on SparkWave™ therapy-induced angiogenesis and regeneration

Response of Post-Mastectomy Lymphedema to Extracorporeal Shockwave Therapy

Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

Latest Basic Research Abstracts

Innovating Plantar Fasciitis Relief with Advanced Shockwave Therapy

EPAT Therapy for Plantar Fasciitis vs Alternatives

2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

Is Shockwave Therapy Covered by Insurance? A Reimbursement Guide for Providers

Is Shockwave Therapy Covered by Insurance? A Reimbursement Guide for Providers

Shock wave treatment for in vitro engineering applications

Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions

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Softwave vs radial

Radial Shockwave Therapy Machines Compared 

Shock wave therapy for systemic sclerosis

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Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.

SoftWave : Transforming Foot Pain Management with Advanced Shockwave Therapy

Chronic Tendonitis Treatment When Injections Have Failed

Chronic Tendonitis Treatment When Injections Have Failed

Spark Wave® Therapy Ameliorates Urinary Incontinence

Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

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Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

Medispec Shockwave Devices- Efficacy & Alternatives

Medispec Shockwave Devices: Efficacy & Alternatives

Stromal Vascular Fraction Combined with Shock Wave for the Treatment of Peyronie’s Disease

Selective sensitiveness of mesenchymal stem cells to shock waves leads to anticancer effect in human cancer cell co-cultures

Extracorporeal Shock Wave Therapy for Treatment of Vulvodynia: A prospective, randomized, double-blind, placebo-controlled study

Shock wave treatment induces angiogenesis and mobilizes endogenous cd31/cd34-positive endothelial cells in a hindlimb ischemia model: implications for angiogenesis and vasculogenesis

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Immunomodulation of Osseointegration Through Extracorporeal Shock Wave Therapy

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

Assessment of IL-1Beta and VEGF Concentration in Rat Model During Orthodontic Tooth Movement and Extracorporeal Shock Wave Therapy

Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement-a randomized clinical trial.

Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

Focused Shockwave Therapy Efficacy & Alternatives

Focused Shockwave Therapy Efficacy & Alternatives

Shockwave Therapy Of The Heart​

Alternatives to Cortisone Shots for Joint Pain Relief

Alternatives to Cortisone Shots for Joint Pain Relief

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

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Indications for shockwaves in veterinary medicine

Can cellulite be treated with low-energy extracorporeal shock wave therapy?

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

Influence of extracorporeal shock wave therapy (ESWT) on bone turnover markers in organisms with normal and low bone mineral density during fracture healing: a randomized clinical trial

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Relief for Back Pain with Innovative Shockwave Therapy

SoftWave ESWT: Redefining Relief for Back Pain with Innovative Shockwave Therapy

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Prophylactic Low-Energy Shock Wave Therapy Improves Wound Healing After Vein Harvesting for Coronary Artery Bypass Graft Surgery: A Prospective, Randomized Trial

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Low Intensity Shockwave Therapy vs High Intensity: Which Works Best?

​Shock waves for arthritis A new form of therapy offers pain relief using sound waves in pets

New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

Shockwave Therapy for Muscle Pain and Injuries

Shockwave Therapy for Muscle Pain and Injuries

The link between shockwaves and innate immunity – the main working mechanism?

CM Shockwave Before And After Use

Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

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COVID-19 pneumonia: different respiratory treatment for different phenotypes?

Dr Irwin Goldstein Dinner Presentation – Nashville

Improvement of adipose tissue-derived cells by low-energy extracorporeal shock wave therapy

​Prospective randomized phase II trial of accelerated reepithelialization

Shockwave Therapy: Does it Hurt?

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SoftWave TRT vs Storz Shockwave Machines Compared

Shock wave-pretreated bone marrow cells further improve left ventricular function after myocardial infarction in rabbits

EPAT Shockwave Therapy Efficacy & Alternatives Explained

EPAT Shockwave Therapy Efficacy & Alternatives Explained

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Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease.

Variable Sound -Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

Best Medical Devices for Treating ACL Injuries 

Best Medical Devices for Treating ACL Injuries 

Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

Erectile Dysfunction and the Shocking Truth: Is Shockwave Therapy Effective

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FDA Tightens Opioid Warning Labels: Here’s the Non-Invasive Alternative Changing Pain Care

Doubts over heart stem-cell therapy

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Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

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How Li-ESWT Works for Patients With ED & Other Indications

The Roll of Spark Waves in the Management of Chronic Wounds.

Mechano-transduction effect of shock waves

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Acoustic Field of a Ballistic Shock Wave Therapy Device

IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

Treatment for osteonecrosis of the femoral head

Early angiogenic response to shock waves in a three-dimensional model of human microvascular endothelial cell culture (HMEC-1)

Effects of ESWT on glycosaminoglycan expression during bone healing

Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo

Shockwave Therapy Helping Patients With Peripheral Artery Disease

Shockwaves Prevent From Heart Failure After Acute Myocardial Ischaemia via RNA/Protein Complexes

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Extracorporeal shock wave therapy: clinical applications and regulation

Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

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Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves

Zimmer enPulsPro Shockwave Machines-

Zimmer enPulsPro Shockwave Machines: Efficacy & Alternatives

Hip Pain Management with Advanced Shockwave Therapy

SoftWave: Revolutionizing Hip Pain Management with Advanced Shockwave Therapy

ESWT in skin & aesthetic indications

Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

Effectiveness of Extracorporeal Shock Wave Lithotripsy to Treat Dystrophic Calcinosis Cutis Ulcers

Improvement of adipose tissue–derived cells by low-energy extracorporeal shock wave therapy

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Comparing Shockwave vs Injection-Based Regenerative Pain Treatments

Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

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Variable Sound-Fields of Electro-Hydraulic Extracorporeal Shockwave Applicators

​Role of extracorporeal shock wave therapy in management of Peyronie’s disease: A preliminary report

Effect of extracorporeal shock wave on proliferation and differentiation of equine adipose tissue-derived mesenchymal stem cells in vitro

In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification

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Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Softwave® Tissue Regeneration Technologies Announces Landmark Trial for Acute Traumatic Spinal Cord Injuries

Shock wave application to cell cultures

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Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure

A First Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial Evaluating Extracorporeal Shock Wave Therapy for the Treatment of Peyronie ’s Disease

Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Lateral epicondylitis: This is still a main indication for extracorporeal shockwave therapy

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Best Noninvasive Options for Regenerative Back Treatment Without Injections

Best Options for Regenerative Back Treatment Without Injections

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A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

Best Medical Devices for Treating Tennis & Golfer’s Elbow

Best Medical Devices for Treating Tennis & Golfer’s Elbow

Evaluation of extracorporeal shock wave therapy for osteoarthritis

Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway

Effects of the extracorporeal shock wave therapy on the skin: an experimental study

Dermapace Machines- Cost, Efficacy, & Alternatives

Dermapace Machines: Cost, Efficacy, & Alternatives

Best Medical Devices for Treating Achilles Tendinitis

Best Medical Devices for Treating Achilles Tendinitis

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Cleveland Clinic – Low Intensity Shockwaves In Urology

The Best Alternatives to Rotator Cuff Surgery

Alternatives to Rotator Cuff Surgery

Preoperative Shockwave Therapy Improves Wound Healing – (Med Esthetics Mag​)

The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.

Analysis of extracorporeal shock wave therapy for Peyronie’s disease

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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Prof. M. Kravchik. Focused shockwave therapy in the treatment of the spine. Oxford, UK Non-invasive treatment of herniated discs by focused shock wave therapy

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Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Expanding Non-Surgical Treatment Options for Meniscus Injuries in Clinical Practice

Best Medical Devices for Treating Carpal Tunnel Syndrome

Best Medical Devices for Treating Carpal Tunnel Syndrome

Extracorporeal shockwave: mechanisms of action and physiological aspects…

AUVA letter‒ Successful treatment of delayed and non-union fractures

Effect of shock waves on macrophages

Extracorporeal shock waves, a new non-surgical method to treat severe burns

A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis

Peripheral Nerve Regeneration

Peripheral Nerve Regeneration

Reduce Inflammation Naturally With Shockwave Therapy

Storz Modulith Shockwave Systems- Mechanisms, Clinical Context, & Alternatives

Storz Modulith Shockwave Machines: Efficacy & Alternatives Explored

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​STORZ MEDICAL’s NEUROLITH® receives CE approval – Transcranial Pulse Stimulation (TPS) on the central nervous system of patients with Alzheimer’s disease

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Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

Effect of Electrohydraulic Extracorporeal Shockwave Therapy on the Repair of Bone Defects Grafted with Particulate Allografts

Effective Medical Devices for Treating Patellar Tendonitis 

Effective Medical Devices for Treating Patellar Tendonitis 

Golfer’s Secret Weapon for Injury Prevention: SoftWave TRT

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Baker’s Cysts

Best Medical Devices for Treating Baker’s Cysts

Optimization of screw fixation in rat bone with extracorporeal shock waves

What Is Pulse Wave Therapy & Does It Work for Patients?

What Is Pulse Wave Therapy & Does It Work for Patients?

Efficacy and safety of extracorporeal shock wave therapy for acute and chronic soft tissue wounds: A systematic review and meta-analysis

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptoms in a first-in-man trial

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UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

The Clinician’s Guide to Shockwave Therapy- Evidence, Safety, and Technology

The Clinician’s Guide to Shockwave Therapy: Evidence, Safety, and Technology

Top Surgeon: SoftWave ‘a superior way to make tissue want to heal’

Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Extracorporeal shockwave: mechanisms of action and physiological aspects for cellulite, body shaping, and localized fat—Systematic review

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves

Extracorporeal Shockwave Therapy for Arthritis Treatment

Extracorporeal shock waves Improve pareses in 8 cases of spinal cord injury and 3 cases of myelomeningocele.

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Unfocused extracorporeal shockwave therapy diminishes bone loss in rats

Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite

DolorClast Therapy- Mechanism, Indications, and Clinical Evidence

DolorClast Therapy: What Is It & Does It Work for Patients?

Veterinary wound care case study

Chattanooga Shockwave Devices Compared- What Clinicians Should Evaluate

Chattanooga Shockwave Therapy Devices Compared

Orthospec Shockwave System Clinical Uses, Evidence, and Limitations

Orthospec ESWT System Explained

Impact of Extracorporeal Shock Wave Therapy (ESWT) on Orthodontic Tooth Movement – A Randomized Clinical Trial

Ultrasound Based Brain Stimulation

​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

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“In vitro” and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells

MTS Spark WaveTM Technology and its mechanism of action in wound management

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal shock-wave therapy reduces progression of knee osteoarthritis in rabbits by reducing nitric oxide level and chondrocyte apoptosis​

OmniWave Shockwave Therapy- Efficacy & Alternatives Explained

OmniWave Shockwave Therapy: Efficacy & Alternatives Explained

Unfocused extracorporeal shock waves induce anabolic effects in rat bone

Extracorporeal Shock Wave Therapy

Shock waves promote spinal cord repair via TLR32

MTS Spark Waves®– an effective therapy option for aesthetic indications Cellulite / Scars / Stretch marks / Lymphoedema / Alopecia -(MTS Science)

​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Shock wave treatment of muscle stem cells – a new implementation for regeneration

Best Medical Devices for Treating Patellar Tendinitis

Best Medical Devices for Treating Patellar Tendinitis

Shock Wave Therapy Enhances Mitochondrial Delivery into Target Cells and Protects against Acute Respiratory Distress Syndrome

The Physics of Shock Wave Lithotripsy

Principles of Shock Wave Therapy

​Antibacterial effects of extracorporeal shock waves

SDSM Spine pain protocol

Comparative study of shockwave therapy and low-level laser therapy effects in patients with myofascial pain syndrome of the trapezius.

Alternative Treatment using Shockwave for Erectile Dysfunction

TISSUE REGENERATION TECHNOLOGIES, LLC Establishment Registration & Device Listing

MTS Spark WavesTM – successfully treating indispositions of the musculoskeletal system

Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis

Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

​Extracorporeal shock wave therapy: What? Why? Safety?

Extracorporeal shockwave therapy for atrophic and oligotrophic nonunion of tibia and femur in high energy trauma patients. Case series.

Set up Instructions

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TRT SoftWaves® – a new regenerative therapy for paraplegia

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Is surgery the only option for bone-on-bone?

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The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease

Shock wave therapy compared with intramedullary screw fixation for nonunion of proximal fifth metatarsal metaphyseal-diaphyseal fractures

In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

Dr. Lohse Bush, first brain treatments

ESWT for resident stress fractures in athletes.

Placebo controlled, prospectively randomized, double-blinded study for the investigation of the effectiveness and safety of the acoustic wave therapy (AWT(®)) for cellulite treatment.

SoftWave on Elbow

Radial Shockwave Therapy Benefits & Alternatives

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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