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SoftWave Research

Newest Research

Click to access Science Compendium List 2024_02_02
European Heart Journal
Sticky Post

SoftWave TRT Affiliate Study Featured in Prominent Medical Journal

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Extracorporeal shock waves, a new non-surgical method to treat severe burns

Extracorporeal Shock Wave Therapy for Digital Ulcers of Systemic Sclerosis: A Phase 2 Pilot Study

SoftWave TRT vs Storz Shockwave Machines Compared

Macrophage migration induces angiogenesis

Temporal and spatial expression of BMP-2 in sub-chondral bone of necrotic femoral heads in rabbits by use of extracorporeal shock waves

Body shaping with acoustic wave therapy AWT(®)/EPAT(®): randomized, controlled study on 14 subjects.

The Best Alternatives to Rotator Cuff Surgery

Alternatives to Rotator Cuff Surgery

Substantial Biomechanical Improvement by Extracorporeal Shockwave Therapy After Surgical Repair of Rodent Chronic Rotator Cuff Tears

Limited shock wave therapy vs sham treatment in men with Peyronie’s disease: results of a prospective randomized controlled double-blind trial

Cellulite and Focused Extracorporeal Shockwave Therapy for Non-Invasive Body Contouring: A Randomized Trial

How Li-ESWT Works for Patients With ED & Other Indications

MTS Spark WavesTM – successfully treating indispositions of the musculoskeletal system

The Role of Shockwaves in the Enhancement of Bone Repair – From Basic Principles to Clinical Application

TRT SoftWaves® – a new regenerative therapy for paraplegia

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7 Red Flags That Signal a Risky Shockwave Device

7 Red Flags That Signal a Risky Shockwave Device

Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart

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Low-Energy Extracorporeal Shock Wave Ameliorates Streptozotocin Induced Diabetes and Promotes Pancreatic Beta Cells Regeneration in a Rat Model

UGA In vitro study: ESWT treatment of platelets causes increased release of growth factors

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED)

Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice

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ISSWSH Abstract

Equine extracorporeal shock wave therapy

SDSM Spine pain protocol

MTS Science White Paper – Softwave – Pain Therapy

Shockwave Therapy vs Therapeutic Ultrasound- Differences, Benefits, and Outcomes

Shockwave Therapy vs Therapeutic Ultrasound: Differences, Benefits, and Outcomes

Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo

Pilot Trial, First Report Worldwide for Li-SWT (unfocused SoftWaves) For the Treatment of Testicles to Improve Testicular Size and Function.

Effect of a Single Administration of Focused Extracorporeal Shock Wave in the Relief of Delayed-Onset Muscle Soreness: Results of a Partially Blinded Randomized Controlled Trial

Shock wave therapy for osteoinduction

Shock wave application to cell cultures

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ESWT for resident stress fractures in athletes.

Storz Modulith Shockwave Systems- Mechanisms, Clinical Context, & Alternatives

Storz Modulith Shockwave Machines: Efficacy & Alternatives Explored

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Natural Remedies for Tendonitis

Urological Times Cover – Scroll to Page 18 – 19

SoftWave OrthoGold

Best Medical Devices for Treating Wrist Tendonitis 

​The biologic effects of SoftWaves and rationale for spine and brain therapy

Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

Alternatives to Cortisone Shots for Joint Pain Relief

Alternatives to Cortisone Shots for Joint Pain Relief

Ultrasound and shock-wave stimulation to promote axonal regeneration following nerve surgery

Assessment of IL-1Beta and VEGF Concentration in Rat Model During Orthodontic Tooth Movement and Extracorporeal Shock Wave Therapy

New Treatment Option for Clinical and Subclinical Mastitis in Dairy Cows Using Acoustic Pulse Technology (APT)

Alternative Treatment using Shockwave for Erectile Dysfunction

Cleveland Clinic – Low Intensity Shockwaves In Urology

Purple Heart Recipient Uses Innovative Technology to Treat Fellow Veterans

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Prospective Randomized Phase II Trial of Accelerated Reepithelialization of Superficial Second-Degree Burn Wounds Using Extracorporeal Shock Wave Therapy

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Shockwave Therapy as First-Line Treatment for Peyronie’s Disease: A Prospective Study

Effectiveness of extracorporeal shock wave for low back pain (A protocol of systematic review)

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Extracorporeal Shock Wave Therapy for Treatment of Vulvodynia: A prospective, randomized, double-blind, placebo-controlled study

Extracorporeal shock wave therapy relieved pain in patients with coccydynia: a report of two cases

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Motor and Sensory Schwann Cell Phenotype

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Spark Wave® Therapy Improves Cardiac Function

MTS Spark Wave Publications – Science Telegram

Ultrasound Brain Stimulation Piloted in Alzheimer Study

LL37 and shock waves

Alternatives to Surgery

​Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions)

Extracorporeal shockwave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

Treatment of scaphoid waist nonunion

Best Medical Devices for Treating Carpal Tunnel Syndrome

Best Medical Devices for Treating Carpal Tunnel Syndrome

Treatment for osteonecrosis of the femoral head

Storz Masterpuls Machines: Cost, Efficacy, & Alternatives 

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia and improves symptomes in a first-in-man trial

Effect of shock waves on macrophages: A possible role in tissue regeneration and remodeling

Immunomodulation of Osseointegration Through Extracorporeal Shock Wave Therapy

Managing Pain with Shockwave Therapy for Muscles

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Extracorporeal Shock Wave Therapy in Peyronie’s Disease: Clinical Efficacy and Safety from a Single-Arm Observational Study

Mechano-transduction effect of shock waves

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Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway

Athletic therapy (Mts-Science)

Shockwave Therapy for Calcific Tendonitis

The Use of Shock Waves in Peripheral Nerve Regeneration:New Perspectives?

SoftWave vs Shockwave Technology Explained 

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Spark Wave® Therapy Improves Full Thickness Skin Defects

Low-energy Extracorporeal Shock Wave Therapy (ESWT) on secondary fibrolymphedema

low intensity softwave in use on arm on a table

What Is Li-ESWT & How Does It Work?

Development of a Prognostic Naïve Bayesian Classifier for Successful Treatment of Nonunions

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Extracorporeal Shockwave Therapy vs Ultrasound Therapy for Plantar Fasciitis

Evaluation of a low-intensity shockwave therapy for chronic prostatitis type IIIb/chronic pelvic pain syndrome: a double-blind randomized sham-controlled clinical trial

Shock Wave Therapy Improves Cardiac Function in a Model of Chronic Ischemic Heart Failure: Evidence for a Mechanism Involving VEGF Signaling and the Extracellular Matrix

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Efficacy of Extracorporeal Shockwave Therapy on Pain and Function in Myofascial Pain Syndrome of the Trapezius: A Systematic Review and Meta-Analysis

Regenerative Restorative Care Treatments Post Knee Surgery

Regenerative Restorative Care Treatments Post Knee Surgery

Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

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Effective Medical Devices for Temporomandibular Joint Dysfunction

Effective Medical Devices for Temporomandibular Joint Dysfunction

2025 AUA Guidelines on Male Chronic Pelvic Pain: Shockwave Therapy Evidence and Clinical Implications

Pulsewave Therapy- Mechanism of Action and Clinical Indications

Pulsewave Therapy Explained: Mechanism of Action and Clinical Indications

Effects of Extracorporeal Shockwave Therapy on Patients with Chronic Low Back Pain and Their Dynamic Balance Ability

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Extracorporeal shock wave therapy for nonunion of the tibia

Effect of Low-energy Extracorporeal Shock Waves on Orthodontic Tooth Movement and Miniscrew Stability

Chronic Tendonitis Treatment When Injections Have Failed

Chronic Tendonitis Treatment When Injections Have Failed

Symptomatic treatment of unresponsive wakefulness syndrome with transcranial focused extracorporeal shock waves

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Response of Post-Mastectomy Lymphedema to Extracorporeal Shockwave Therapy

Low Intensity Shock Wave Therapy: Regenerative Therapy for Erectile Dysfunction

Unfocused extracorporeal shock waves induce anabolic effects in rat bone

Extracorporeal shockwave therapy shows site-specific effects in osteoarthritis of the knee in rats

Do Gymna Shockmaster Machines Work for Patients?

Do Gymna Shockmaster Machines Work for Patients?

Effects of Extracorporeal Shock Wave Therapy on Spasticity in Patients after Brain Injury: A Meta-analysis

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Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study

Clinical evidence of SparkWave™ therapy in the treatment of erectile dysfunction

How to Manage Pain Without Drugs

Shock Wave Therapy (MI-ESWT) for Plantar Fasciitis

​Extracorporeal shock wave therapy: What? Why? Safety?

The Exosome – A Naturally Secreted Nanoparticle and its Application to Wound Healing.

In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

Doctor Uses Shockwave Therapy to Heal Nearly Severed Foot

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Clinical Outcomes of Extracorporeal Shock Wave Therapy in Patients With Secondary Lymphedema: A Pilot Study

Epicardial shock-wave therapy improves ventricular function in a porcine model of ischaemic heart disease

Regenerative Therapies for Hip Pain and Tendinopathy

Regenerative Therapies for Hip Pain and Tendinopathy

OmniWave Shockwave Therapy- Efficacy & Alternatives Explained

OmniWave Shockwave Therapy: Efficacy & Alternatives Explained

Erectile Dysfunction and the Shocking Truth: Is Shockwave Therapy Effective

Can You Use a Shockwave Therapy Machine at Home?

Effect of Extracorporeal Shockwave Therapy (ESWT) on Pulpal Blood Flow After Orthodontic Treatment: A Randomized Clinical Trial

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Shock wave therapy causes increased macrophage recruitment and enhances M2 polarization

Piezowave Shockwave Therapy vs Other Shockwave Devices

Piezowave Shockwave Therapy vs Other Shockwave Devices

Extracorporal SoftWave Treatment to Improve Nerve Regeneration

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​Therapeutic effects of Low intensity extracorporeal low energy shock wave therapy (LiESWT) on stress urinary incontinence

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves?

Effect of shock waves on macrophages

Benefit of combined extracorporeal shock wave and bone marrow-derived endothelial progenitor cells in protection against critical limb ischemia in rats

Angiogenic response to extracorporeal shock wave treatment in murine skin isografts

Extracorporeal shockwave therapy versus exercise program in patients with low back pain: short-term results of a randomised controlled trial.

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Antimicrobial peptide LL37/RNA complexes stimulate Toll-like receptor 3 upon shock wave therapy

Influence of medical shock waves on healthy muscle tissue

Storz Duolith Machines- Cost, Efficacy, & Alternatives

Storz Duolith Machines Compared

Treatment of stress urinary incontinence

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The effect of shock waves on in vitro cartilage development in silk scaffolds

Top Surgeon: SoftWave ‘a superior way to make tissue want to heal’

Best Medical Devices for Treating Patellar Tendinitis

Best Medical Devices for Treating Patellar Tendinitis

The Effect of Different Doses of Extracorporeal Shock Waves on Experimental Model Mandibular Distraction

Regenerative Skin Treatment for Burns, Scars, and Wounds

Regenerative Skin Treatment for Burns, Scars, and Wounds

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

Shockwave Therapy for the Treatment of Cancer

Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

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Mesenchymal stem cells: Myths and reality

SoftWave Therapy for Knees

SoftWave Therapy vs. Stem Wave & Acoustic Wave Devices for Knee Pain

10 Natural Ways to Find Pain Relief

ESWT in skin & aesthetic indications

Morton's Neuroma

Effective Medical Devices for Treating Morton’s Neuroma

Acoustic Field of a Ballistic Shock Wave Therapy Device

Extracorporeal shock wave therapy for calcifying tendinitis of the shoulder

Sound Frequency Healing: The Spark of Life

Shockwave therapy in stress fractures

MTS Spark Waves®– an effective therapy option for aesthetic indications Cellulite / Scars / Stretch marks / Lymphoedema / Alopecia -(MTS Science)

Extracorporeal shockwave therapy induces alveolar bone regeneration

Low–Energy Shockwave Therapy Improves Ischemic Kidney Microcirculation

Complementary effect of L-citrulline supplementation on SparkWave™ therapy-induced angiogenesis and regeneration

Prospective randomized trial of accelerated re- epithelization of skin graft donor sites using extracorporeal shock wave therapy

Plantar Fasciitis Medical Devices That Relieve Pain

Plantar Fasciitis Medical Devices That Relieve Pain

Angiogenic response upon shock wave treatment of the ischaemic muscle

Alternatives to Back Surgery Doctors Should Consider

Alternatives to Back Surgery Doctors Should Consider

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​Update on the efficacy of extracorporeal shockwave treatment for myofascial pain syndrome and fibromyalgia

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Comparative analysis of angiogenic gene expression in normal and impaired wound healing in diabetic mice: Effects of extracorporeal shock wave therapy

A study to identify the potential effects of extracorporeal shockwave therapy alone and in combination with Avastin.

ISMST (International Society for Medical Shockwave Treatment)

Ultrasound Based Brain Stimulation

Extracorporeal shockwave treatment: A novel tool to improve Schwann cell isolation and culture

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Effectiveness of shock wave therapy: implementation of a soft wide focus applicator in patients with erectile dysfunction

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Shock wave treatment after hindlimb ischemia results in increased perfusion and M2 macrophage presence

​Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy

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A neural model for chronic pain and pain relief by extracorporeal shock wave treatment

Low-energy extracorporeal shock wave therapy for a model of liver cirrhosis ameliorates liver fibrosis and liver function

Zapping chronic tendon pain

Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat

The Biologic Effects of SoftWaves™and Rationale for Spine and Brain Therapy

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Latest Basic Research Abstracts

Cellular signaling pathways modulated by low-intensity extracorporeal shock wave therapy

Extracorporeal shockwave therapy (ESWT) First choice treatment of fracture non-unions?

SoftWave : Transforming Foot Pain Management with Advanced Shockwave Therapy

The Applied Mechanical Vibration as Extracorporeal Shock Wave

Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Radial or Focused Shockwave Therapy? When to Use Each in Clinical Practice

Efficacy of extracorporeal shock wave therapy (ESWT) for males chronic pelvic pain syndrome

Acoustic Wave Therapy vs Shockwave Therapy

Project: SoftWaves to prevent opioid addiction and to help addicts in their recovery.

Extracorporeal shock wave therapy (ESWT) for the treatment of spasticity in persons with spinal cord injury

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Unfocused extracorporeal shock waves induce anabolic effects in osteoporotic rats

Shock wave treatment reduces neuronal degeneration upon spinal cord ischemia vi a Toll-like receptor 3 dependent mechanism

Impact of extracorporeal shock-wave therapy on the stability of temporary anchorage devices in adults: a single-center, randomized, placebo-controlled clinical trial.

Shock wave treatment enhances stemness and preserves multipotency

In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes

Shockwave Therapy Helping Patients With Peripheral Artery Disease

Shock Wave Treatment Protects From Neuronal Degeneration via a Toll-Like Receptor 3 Dependent Mechanism: Implications of a First-Ever Causal Treatment for Ischemic Spinal Cord Injury

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Integrating Regenerative Treatments for Ankle Pain in Active Patients

Integrating Regenerative Treatments for Ankle Pain in Active Patients

Shock waves induce angiogenesis via exosome release

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Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

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Best Medical Devices for Treating Tennis & Golfer’s Elbow

Best Medical Devices for Treating Tennis & Golfer’s Elbow

The Basic Science Behind Low-Intensity Extracorporeal Shockwave Therapy for Erectile Dysfunction

DolorClast Therapy- Mechanism, Indications, and Clinical Evidence

DolorClast Therapy: What Is It & Does It Work for Patients?

Regenerative Treatments for Athletes and Their Role Compared With Surgical Repair

Regenerative Treatments for Athletes Versus Surgical Repair

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy

MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

Extracorporeal shockwave therapy for atrophic and oligotrophic nonunion of tibia and femur in high energy trauma patients. Case series.

Orthospec Shockwave System Clinical Uses, Evidence, and Limitations

Orthospec ESWT System Explained

Effectiveness of Extracorporeal Shock Wave Lithotripsy to Treat Dystrophic Calcinosis Cutis Ulcers

Extracorporeal shockwave therapy (ESWT) e First choice treatment of fracture non-unions?

Optimal timing of extracorporeal shock wave treatment to protect ischemic tissue

Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Extracorporeal shockwave therapy (ESWT) in the treatment of atrophic non-unions of femoral shaft fractures

Benefits of Spark Wave Therapy in neuronal regeneration

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Impact of extracorporeal shock wave therapy (ESWT) on orthodontic tooth movement—a randomized clinical trial​

Peyronie’s disease and low intensity shock wave therapy: Clinical outcomes and patient satisfaction rate in an open-label single arm prospective study in Australian men

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Biologic Response

The link between shockwaves and innate immunity – the main working mechanism?

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LL37 and shock waves

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IVSWT Water Bath V2.0: Standardized model for in-vitro shock wave treatment (IVSWT)

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Biological Principles – Mechanotransduction

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Biological mechanism of musculoskeletal shockwaves

Shock waves are defined as types of acoustic pressure waves that develop during sudden releases...
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​The biologic effects of SoftWaves and rationale for spine and brain therapy

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IVSWT Water Bath V2.0 Manual

The number of in-vitro experiments in shock wave science increases continuously. This fact reflects how...
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​Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of...
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Shock wave application to cell cultures

Shock waves nowadays are well known for their regenerative effects. Basic research findings showed that...
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Shockwave treatment enhances cell proliferation and improves wound healing

Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying...
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Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction

Extracorporeal Shock Wave Therapy (ESWT) is a form of “mechanotherapy”, that, from its original applications...
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Latest Basic Research Abstracts

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Lohse – Busch ISMST Presentation

High-energy ESW can destroy non myelinated nerves but afterwards there is an even faster regeneration....
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Effect of shock waves on macrophages

Extracorporeal Shock Wave Therapy (ESWT) is broadly used as a non-surgical therapy in various diseases...
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Shockwaves prevent from heart failure after acute myocardial ischemia via RNA/protein complexes

Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3)....
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Focused high‐energy extracorporeal shockwaves as supplemental treatment in a rabbit model of fracture‐related infection

Focused high‐energy extracorporeal shockwave therapy (fhESWT) is used to improve fracture healing in cases of...
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Toll-like receptor 3 signalling mediates angiogenic response upon shock wave treatment of ischaemic muscle

Shock wave therapy (SWT) represents a clinically widely used angiogenic and thus regenerative approach for...
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Shockwave therapy differentially stimulates endothelial cells: implications on the control of inflammation via toll-like receptor 3

(Johannes Holfeld, Can Tepeköylü, Radoslaw Kozaryn, Anja Urbschat, Kai Zacharowski, Michael Grimm, and Patrick Paulus)...
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Low energy shock wave therapy induces angiogenesis in acute hind-limb ischemia via VEGF receptor 2 phosphorylation

(​University Hospital for Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria, 2 Division of Clinical and...
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